PRMT3 promotes tumorigenesis by methylating and stabilizing HIF1α in colorectal cancer

Abstract Abnormal angiogenesis occurs during the growth of solid tumors resulting in increased vascular permeability to fluids and metastatic cancer cells. Anti-angiogenesis therapy for solid tumors is effective in the treatment of cancer patients. However, the efficacy of anti-angiogenesis therapy...

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Bibliographic Details
Main Authors: Xin Zhang, Kexin Wang, Xingbo Feng, Jian Wang, Yali Chu, Chunmeng Jia, Qingsi He, Cheng Chen
Format: Article
Language:English
Published: Nature Publishing Group 2021-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04352-w