Curcumin regulates autophagy through SIRT3-SOD2-ROS signaling pathway to improve quadriceps femoris muscle atrophy in KOA rat model

Curcumin regulates autophagy through SIRT3-SOD2-ROS signaling pathway to improve quadriceps femoris muscle atrophy in KOA rat model

Abstract Knee osteoarthritis (KOA) usually leads to quadriceps femoris atrophy, which in turn can further aggravate the progression of KOA. Curcumin (CUR) has anti-inflammatory and antioxidant effects and has been shown to be a protective agent for skeletal muscle. CUR has been shown to have a prote...

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Bibliographic Details
Main Authors: Hua Ye, Yi Long, Jia-Ming Yang, Yan-Lin Wu, Ling-Yan Dong, Yan-Biao Zhong, Yun Luo, Mao-Yuan Wang
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Scientific Reports
Subjects:
Knee osteoarthritis
Quadriceps femoris muscle
Curcumin
Autophagy
Online Access:https://doi.org/10.1038/s41598-024-58375-2

Internet

https://doi.org/10.1038/s41598-024-58375-2

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