Discrete Mechanistic Target of Rapamycin Signaling Pathways, Stem Cells, and Therapeutic Targets

Discrete Mechanistic Target of Rapamycin Signaling Pathways, Stem Cells, and Therapeutic Targets

The mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that functions via its discrete binding partners to form two multiprotein complexes, mTOR complex 1 and 2 (mTORC1 and mTORC2). Rapamycin-sensitive mTORC1, which regulates protein synthesis and cell growth, is tightly controlled...

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Bibliographic Details
Main Authors: Meena Jhanwar-Uniyal, Sabrina L. Zeller, Eris Spirollari, Mohan Das, Simon J. Hanft, Chirag D. Gandhi
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cells
Subjects:
mTOR
mTORC1
mTORC2
S6K
4E-BP1
GBM
Online Access:https://www.mdpi.com/2073-4409/13/5/409

Internet

https://www.mdpi.com/2073-4409/13/5/409

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