Stem Cell-Derived Viral Antigen-Specific T Cells Suppress HIV Replication and PD-1 Expression on CD4+ T Cells

Stem Cell-Derived Viral Antigen-Specific T Cells Suppress HIV Replication and PD-1 Expression on CD4+ T Cells

The viral antigen (Ag)-specific CD8+ cytotoxic T lymphocytes (CTLs) derived from pluripotent stem cells (PSCs), i.e., PSC-CTLs, have the ability to suppress the human immunodeficiency virus (HIV) infection. After adoptive transfer, PSC-CTLs can infiltrate into the local tissues to suppress HIV repli...

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Bibliographic Details
Main Authors: Mohammad Haque, Fengyang Lei, Xiaofang Xiong, Yijie Ren, Hao-Yun Peng, Liqing Wang, Anil Kumar, Jugal Kishore Das, Jianxun Song
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Viruses
Subjects:
HIV
stem cells
cell differentiation
T cells
viral antigen
viral replication
Online Access:https://www.mdpi.com/1999-4915/13/5/753

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https://www.mdpi.com/1999-4915/13/5/753

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