Synthesis and Biological Evaluation of 5′-<i>O</i>-Fatty Acyl Ester Derivatives of 3′-Fluoro-2′,3′-dideoxythymidine as Potential Anti-HIV Microbicides

Synthesis and Biological Evaluation of 5′-<i>O</i>-Fatty Acyl Ester Derivatives of 3′-Fluoro-2′,3′-dideoxythymidine as Potential Anti-HIV Microbicides

A number of 5′-<i>O</i>-fatty acyl derivatives of 3′-fluoro-2′,3′-dideoxythymidine (FLT, <b>1</b>) were synthesized. These conjugates were evaluated for their potential as topical microbicides with anti-HIV activity against cell-free (X4 and R5), cell-associated, and multidru...

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Bibliographic Details
Main Authors: Hitesh K. Agarwal, Bhupender S. Chhikara, Guofeng Ye, Sitaram Bhavaraju, Ajay Dixit, Anil Kumar, Gustavo F. Doncel, Keykavous Parang
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Molecules
Subjects:
anti-HIV
cellular uptake
cytotoxicity
fatty acids
3′-fluoro-2′,3′-dideoxythymidine
multidrug-resistant
Online Access:https://www.mdpi.com/1420-3049/27/10/3352

Internet

https://www.mdpi.com/1420-3049/27/10/3352

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