Liquorice Extract and 18β-Glycyrrhetinic Acid Protect Against Experimental Pyrrolizidine Alkaloid-Induced Hepatotoxicity in Rats Through Inhibiting Cytochrome P450-Mediated Metabolic Activation

Liquorice Extract and 18β-Glycyrrhetinic Acid Protect Against Experimental Pyrrolizidine Alkaloid-Induced Hepatotoxicity in Rats Through Inhibiting Cytochrome P450-Mediated Metabolic Activation

Misuse of pyrrolizidine alkaloid (PA)-containing plants or consumption of PA-contaminated foodstuffs causes numerous poisoning cases in humans yearly, while effective therapeutic strategies are still limited. PA-induced liver injury was initiated by cytochrome P450 (CYP)-mediated metabolic activatio...

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Bibliographic Details
Main Authors: Zhangting Wang, Jiang Ma, Sheng Yao, Yisheng He, Kai-Kei Miu, Qingsu Xia, Peter P. Fu, Yang Ye, Ge Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
18β-glycyrrhetinic acid
pyrrolizidine alkaloid
cytochrome P450
metabolic activation
competitive inhibition
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.850859/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.850859/full

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