Fingolimod prevents blood-brain barrier disruption induced by the sera from patients with multiple sclerosis.

Fingolimod prevents blood-brain barrier disruption induced by the sera from patients with multiple sclerosis.

OBJECTIVE: Effect of fingolimod in multiple sclerosis (MS) is thought to involve the prevention of lymphocyte egress from lymphoid tissues, thereby reducing autoaggressive lymphocyte infiltration into the central nervous system across blood-brain barrier (BBB). However, brain microvascular endotheli...

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Bibliographic Details
Main Authors: Hideaki Nishihara, Fumitaka Shimizu, Yasuteru Sano, Yukio Takeshita, Toshihiko Maeda, Masaaki Abe, Michiaki Koga, Takashi Kanda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4361641?pdf=render

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http://europepmc.org/articles/PMC4361641?pdf=render

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