Ionic Liquid Forms of the Antimalarial Lumefantrine in Combination with LFCS Type IIIB Lipid-Based Formulations Preferentially Increase Lipid Solubility, In Vitro Solubilization Behavior and In Vivo Exposure

Ionic Liquid Forms of the Antimalarial Lumefantrine in Combination with LFCS Type IIIB Lipid-Based Formulations Preferentially Increase Lipid Solubility, In Vitro Solubilization Behavior and In Vivo Exposure

Lipid based formulations (LBFs) are commonly employed to enhance the absorption of highly lipophilic, poorly water-soluble drugs. However, the utility of LBFs can be limited by low drug solubility in the formulation. Isolation of ionizable drugs as low melting, lipophilic salts or ionic liquids (ILs...

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Bibliographic Details
Main Authors: Erin Tay, Tri-Hung Nguyen, Leigh Ford, Hywel D. Williams, Hassan Benameur, Peter J. Scammells, Christopher J. H. Porter
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Pharmaceutics
Subjects:
ionic liquid
lipophilic salt
drug delivery
drug absorption
poorly water-soluble drug
lumefantrine
lipid-based formulation
sedds
lipid formulation classification system
Online Access:https://www.mdpi.com/1999-4923/12/1/17

Internet

https://www.mdpi.com/1999-4923/12/1/17

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