Beneficial impact of CCL2 and CCL12 neutralization on experimental malignant pleural effusion.

Beneficial impact of CCL2 and CCL12 neutralization on experimental malignant pleural effusion.

Using genetic interventions, we previously determined that C-C motif chemokine ligand 2 (CCL2) promotes malignant pleural effusion (MPE) formation in mice. Here we conducted preclinical studies aimed at assessing the specific therapeutic potential of antibody-mediated CCL2 blockade against MPE. For...

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Bibliographic Details
Main Authors: Antonia Marazioti, Chrysoula A Kairi, Magda Spella, Anastasios D Giannou, Sophia Magkouta, Ioanna Giopanou, Vassilios Papaleonidopoulos, Ioannis Kalomenidis, Linda A Snyder, Dimitrios Kardamakis, Georgios T Stathopoulos
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3743892?pdf=render

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http://europepmc.org/articles/PMC3743892?pdf=render

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