CBX2 shapes chromatin accessibility promoting AML via p38 MAPK signaling pathway

CBX2 shapes chromatin accessibility promoting AML via p38 MAPK signaling pathway

Abstract Background The dynamic epigenome and proteins specialized in the interpretation of epigenetic marks critically contribute to leukemic pathogenesis but also offer alternative therapeutic avenues. Targeting newly discovered chromatin readers involved in leukemogenesis may thus provide new ant...

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Bibliographic Details
Main Authors: Nunzio Del Gaudio, Antonella Di Costanzo, Ning Qing Liu, Lidio Conte, Carmela Dell’Aversana, Guglielmo Bove, Rosaria Benedetti, Liliana Montella, Fortunato Ciardiello, Vincenzo Carafa, Concetta Ambrosino, Valeria Tucci, Mariarosaria Conte, Joost H. A. Martens, Hendrik G. Stunnenberg, Angela Nebbioso, Lucia Altucci
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Molecular Cancer
Subjects:
PcG
Leukemia
CBX2
Epigenetics
Chromatin readers
Cancer
Online Access:https://doi.org/10.1186/s12943-022-01603-y

Internet

https://doi.org/10.1186/s12943-022-01603-y

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