Identification of Vinyl Sulfone Derivatives as EGFR Tyrosine Kinase Inhibitor: In Vitro and In Silico Studies

Identification of Vinyl Sulfone Derivatives as EGFR Tyrosine Kinase Inhibitor: In Vitro and In Silico Studies

Epidermal growth factor receptor (EGFR), overexpressed in many types of cancer, has been proved as a high potential target for targeted cancer therapy due to its role in regulating proliferation and survival of cancer cells. In the present study, a series of designed vinyl sulfone derivatives was sc...

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Bibliographic Details
Main Authors: Thitinan Aiebchun, Panupong Mahalapbutr, Atima Auepattanapong, Onnicha Khaikate, Supaphorn Seetaha, Lueacha Tabtimmai, Chutima Kuhakarn, Kiattawee Choowongkomon, Thanyada Rungrotmongkol
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Molecules
Subjects:
EGFR tyrosine kinase
vinyl sulfone derivatives
in silico study
kinase assay
cytotoxicity assay
Online Access:https://www.mdpi.com/1420-3049/26/8/2211

Internet

https://www.mdpi.com/1420-3049/26/8/2211

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