Heterologous production of the adhesin LIC13411 from pathogenic Leptospira facilitates binding of non-pathogenic Leptospira in vitro and in vivo

Heterologous production of the adhesin LIC13411 from pathogenic Leptospira facilitates binding of non-pathogenic Leptospira in vitro and in vivo

Leptospirosis is an important cause of morbidity and mortality worldwide. Disease severity ranges from asymptomatic colonization to widespread hemorrhage and multiorgan dysfunction. The causative agents, Leptospira spp., are zoonotic Gram-negative spirochetes. One important step in pathogenesis is b...

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Bibliographic Details
Main Authors: Matthew C. Surdel, Beth L. Hahn, Phillip N. Anderson, Jenifer Coburn
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Leptospira
infectious disease
bacteria
adhesin
VE-cadherin
endothelial cells
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.917963/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.917963/full

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