Hydrogen sulfide protects cardiomyocytes from doxorubicin-induced ferroptosis through the SLC7A11/GSH/GPx4 pathway by Keap1 S-sulfhydration and Nrf2 activation

Hydrogen sulfide protects cardiomyocytes from doxorubicin-induced ferroptosis through the SLC7A11/GSH/GPx4 pathway by Keap1 S-sulfhydration and Nrf2 activation

Recent studies have demonstrated that ferroptosis, a novel form of nonapoptotic regulated cell death plays an important role in doxorubicin (DOX)-induced cardiotoxicity (DoIC). Hydrogen sulfide (H2S) is emerging as the third important gaseous mediator in cardiovascular system. However, whether H2S h...

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Bibliographic Details
Main Authors: Hui Zhang, Jianan Pan, Shuying Huang, Xiaonan Chen, Alex Chia Yu Chang, Changqian Wang, Junfeng Zhang, Huili Zhang
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Redox Biology
Subjects:
Doxorubicin-induced cardiotoxicity
Hydrogen sulfide
Ferroptosis
SLC7A11
S-sulfhydrated Keap1
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724000429

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http://www.sciencedirect.com/science/article/pii/S2213231724000429

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