Macrophage targeted polymeric curcumin nanoparticles limit intracellular survival of Mycobacterium tuberculosis through induction of autophagy and augment anti-TB activity of isoniazid in RAW 264.7 macrophages

Macrophage targeted polymeric curcumin nanoparticles limit intracellular survival of Mycobacterium tuberculosis through induction of autophagy and augment anti-TB activity of isoniazid in RAW 264.7 macrophages

Rapid emergence of antibiotic resistance in tuberculosis has left us with limited resources to treat and manage multi drug resistant (MDR) cases of tuberculosis, prompting the development of novel therapeutics. Mycobacterium tuberculosis (MTB) perturbs the host protective pathways for its survival,...

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Bibliographic Details
Main Authors: Pramod Kumar Gupta, Priyanka Jahagirdar, Devavrat Tripathi, Padma V. Devarajan, Savita Kulkarni
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
mycobacterium tuberculosis
autophagy
host-directed therapeutics
curcumin
multi drug resistance
phagosome lysosome fusion
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1233630/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1233630/full

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