Effects of miR-204-5p modulation on PAX6 regulation and corneal inflammation

Effects of miR-204-5p modulation on PAX6 regulation and corneal inflammation

Abstract Congenital aniridia is a rare eye disease characterized by loss of PAX6 protein leading to aniridia-associated keratopathy that significantly reduces vision. The miR-204-5p is a possible regulator of PAX6 function and here we evaluate its effect in multiple in vitro and in vivo models. In v...

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Bibliographic Details
Main Authors: Mojdeh Abbasi, Maryam Amini, Petros Moustardas, Quirin Gutsmiedl, Dina Javidjam, Shweta Suiwal, Berthold Seitz, Fabian N. Fries, Ava Dashti, Yedizza Rautavaara, Tanja Stachon, Nóra Szentmáry, Neil Lagali
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Aniridia
MiR-204-5p
PAX6
Keratitis
Corneal inflammation
Online Access:https://doi.org/10.1038/s41598-024-76654-w

Internet

https://doi.org/10.1038/s41598-024-76654-w

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