Cancer-Specific Delivery of Proteolysis-Targeting Chimeras (PROTACs) and Their Application to Cancer Immunotherapy

Cancer-Specific Delivery of Proteolysis-Targeting Chimeras (PROTACs) and Their Application to Cancer Immunotherapy

Proteolysis-targeting chimeras (PROTACs) are rapidly emerging as a potential therapeutic strategy for cancer therapy by inducing the degradation of tumor-overexpressing oncogenic proteins. They can specifically catalyze the degradation of target oncogenic proteins by recruiting E3 ligases and utiliz...

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Bibliographic Details
Main Authors: Yujeong Moon, Seong Ik Jeon, Man Kyu Shim, Kwangmeyung Kim
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceutics
Subjects:
proteolysis-targeting chimera (PROTAC)
protein degradation
drug delivery system
cancer-targeted therapy
cancer immunotherapy
Online Access:https://www.mdpi.com/1999-4923/15/2/411

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https://www.mdpi.com/1999-4923/15/2/411

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