TNF-α inhibitor ameliorates immune-related arthritis and pneumonitis in humanized mice

TNF-α inhibitor ameliorates immune-related arthritis and pneumonitis in humanized mice

ObjectivesThis study aimed at establishing a mouse model of immune-related adverse in humanized BALB/c-hPD1/hCTLA4 mice to investigate their potential pathogenesis and explore therapeutic targets for immune-related arthritis and pneumonitis.MethodsHumanized BALB/c-hPD1/hCTLA4 mice were injected with...

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Bibliographic Details
Main Authors: Jian Gao, Jinlin Miao, Haoyang Sun, Xianghui Fu, Peiyan Zhang, Zhinan Chen, Ping Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
TNF-α
immune checkpoint
immunotherapy
humanized mouse
pneumonitis
arthritis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.955812/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.955812/full

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