Emodin Protects Against Lipopolysaccharide-Induced Acute Lung Injury via the JNK/Nur77/c-Jun Signaling Pathway

Emodin Protects Against Lipopolysaccharide-Induced Acute Lung Injury via the JNK/Nur77/c-Jun Signaling Pathway

Background: Acute lung injury (ALI) is a serious inflammatory disease with clinical manifestations of hypoxemia and respiratory failure. Presently, there is no effective treatment of ALI. Although emodin from Rheum palmatum L. exerts anti-ALI properties, the underlying mechanisms have not been fully...

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Bibliographic Details
Main Authors: Pei Xie, Li-Jun Yan, Hong-Ling Zhou, Hui-Hui Cao, Yuan-Ru Zheng, Zi-Bin Lu, Hua-Yi Yang, Jia-Mei Ma, Yu-Yao Chen, Chuying Huo, Chunyang Tian, Jun-Shan Liu, Lin-Zhong Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
acute lung injury
inflammation
lipopolysaccharide
emodin
JNK/Nur77/c-Jun
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.717271/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.717271/full

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