Characterization of the novel heterozygous SCN5A genetic variant Y739D associated with Brugada syndrome

Characterization of the novel heterozygous SCN5A genetic variant Y739D associated with Brugada syndrome

Genetic variants in SCN5A gene were identified in patients with various arrhythmogenic conditions including Brugada syndrome. Despite significant progress of last decades in studying the molecular mechanism of arrhythmia-associated SCN5A mutations, the understanding of relationship between genetics,...

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Bibliographic Details
Main Authors: Anastasia K. Zaytseva, Artem M. Kiselev, Alexander S. Boitsov, Yulia V. Fomicheva, Georgii S. Pavlov, Boris S. Zhorov, Anna A. Kostareva
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Biochemistry and Biophysics Reports
Subjects:
Brugada syndrome
Sodium channel
SCN5A
Sodium channelopathies
Homology modeling
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580822000498

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http://www.sciencedirect.com/science/article/pii/S2405580822000498

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