Thyroid Autoantibodies Display both “Original Antigenic Sin” and Epitope Spreading

Thyroid Autoantibodies Display both “Original Antigenic Sin” and Epitope Spreading

Evidence for original antigenic sin in spontaneous thyroid autoimmunity is revealed by autoantibody interactions with immunodominant regions on thyroid autoantigens, thyroglobulin (Tg), thyroid peroxidase (TPO), and the thyrotropin receptor (TSHR) A-subunit. In contrast, antibodies induced by immuni...

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Bibliographic Details
Main Authors: Sandra M. McLachlan, Basil Rapoport
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
thyroid autoantibodies
intermolecular and intramolecular epitope spreading
immunodominant region
original antigenic sin
thyroglobulin
thyroid peroxidase
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01845/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01845/full

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