Longitudinal spatial mapping of lipid metabolites reveals pre-symptomatic changes in the hippocampi of Huntington's disease transgenic mice

Longitudinal spatial mapping of lipid metabolites reveals pre-symptomatic changes in the hippocampi of Huntington's disease transgenic mice

In Huntington's disease (HD), a key pathological feature includes the development of inclusion-bodies of fragments of the mutant huntingtin protein in the neurons of the striatum and hippocampus. To examine the molecular changes associated with inclusion-body formation, we applied MALDI-mass sp...

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Bibliographic Details
Main Authors: Farheen Farzana, Malcolm J. McConville, Thibault Renoir, Shanshan Li, Shuai Nie, Harvey Tran, Anthony J. Hannan, Danny M. Hatters, Berin A. Boughton
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Neurobiology of Disease
Subjects:
Neurodegeneration
Kinetic mass spectrometry imaging (kMSI)
Deuterium labelling
Huntingtin inclusions
Neuronal membrane lipids
In vivo metabolic activity
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122003254

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http://www.sciencedirect.com/science/article/pii/S0969996122003254

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