Pharmacologic inhibition of IL11/STAT3 signaling increases MHC-I expression and T cell infiltration

Pharmacologic inhibition of IL11/STAT3 signaling increases MHC-I expression and T cell infiltration

Abstract Background Recent studies have discovered an emerging role of IL11 in various colitis-associated cancers, suggesting that IL11 mainly promotes tumor cell survival and proliferation in regulating tumorigenesis. Herein we aimed to reveal a novel function of IL-11 through STAT3 signaling in re...

Full description

Bibliographic Details
Main Authors: Wenjun Xiong, Yuehong Chen, Chaoting Zhang, Jin Li, Haipeng Huang, Yu Zhu, Guangxu Deng, Junhong Cheng, Yixiong Lin, Zhimin Shi, Tingyu Mou
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Translational Medicine
Subjects:
Colorectal cancer
IL11/STAT3 signaling
CD8+ T infiltration
IFNγ/STAT1
MHC-I molecules
Online Access:https://doi.org/10.1186/s12967-023-04079-6

Internet

https://doi.org/10.1186/s12967-023-04079-6

Similar Items