Comparison of discriminative motif optimization using matrix and DNA shape-based models
Abstract Background Transcription factor (TF) binding site specificity is commonly represented by some form of matrix model in which the positions in the binding site are assumed to contribute independently to the site’s activity. The independence assumption is known to be an approximation, often a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-03-01
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| Series: | BMC Bioinformatics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12859-018-2104-7 |