Brain Regional Identity and Cell Type Specificity Landscape of Human Cortical Organoid Models

Brain Regional Identity and Cell Type Specificity Landscape of Human Cortical Organoid Models

In vitro models of corticogenesis from pluripotent stem cells (PSCs) have greatly improved our understanding of human brain development and disease. Among these, 3D cortical organoid systems are able to recapitulate some aspects of in vivo cytoarchitecture of the developing cortex. Here, we tested t...

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Bibliographic Details
Main Authors: Manuela Magni, Beatrice Bossi, Paola Conforti, Maura Galimberti, Fabio Dezi, Tiziana Lischetti, Xiaoling He, Roger A. Barker, Chiara Zuccato, Ira Espuny-Camacho, Elena Cattaneo
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
hPSC-derived 3D brain organoid models
default and directed differentiation protocols
brain regional identity
neuronal maturation
cell type specificity
Online Access:https://www.mdpi.com/1422-0067/23/21/13159

Internet

https://www.mdpi.com/1422-0067/23/21/13159

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