α-Tocopherol Attenuates Oxidative Phosphorylation of CD34<sup>+</sup> Cells, Enhances Their G0 Phase Fraction and Promotes Hematopoietic Stem and Primitive Progenitor Cell Maintenance

α-Tocopherol Attenuates Oxidative Phosphorylation of CD34<sup>+</sup> Cells, Enhances Their G0 Phase Fraction and Promotes Hematopoietic Stem and Primitive Progenitor Cell Maintenance

Alpha tocopherol acetate (αTOA) is an analogue of alpha tocopherol (αTOC) that exists in the form of an injectable drug. In the context of the metabolic hypothesis of stem cells, we studied the impact of αTOA on the metabolic energetic profile and functional properties of hematopoietic stem and prog...

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Bibliographic Details
Main Authors: Laura Rodriguez, Pascale Duchez, Nicolas Touya, Christelle Debeissat, Amélie V. Guitart, Jean-Max Pasquet, Marija Vlaski-Lafarge, Philippe Brunet de la Grange, Zoran Ivanovic
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Biomolecules
Subjects:
α-tocopherol acetate
hematopoietic stem cells
hematopoietic progenitors
electron transport chain
proliferative capacity
quiescence
Online Access:https://www.mdpi.com/2218-273X/11/4/558

Internet

https://www.mdpi.com/2218-273X/11/4/558

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