The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion

The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion

Abstract As a strategy to improve the therapeutic success of chimeric antigen receptor T cells (CART) directed against solid tumors, we here test the combinatorial use of CART and IMSA101, a newly developed stimulator of interferon genes (STING) agonist. In two syngeneic tumor models, improved overa...

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Bibliographic Details
Main Authors: Ugur Uslu, Lijun Sun, Sofia Castelli, Amanda V. Finck, Charles-Antoine Assenmacher, Regina M. Young, Zhijian J. Chen, Carl H. June
Format: Article
Language:English
Published: Nature Portfolio 2024-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47692-9

Internet

https://doi.org/10.1038/s41467-024-47692-9

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