A Mathematical Approach Using Strat-M<sup>®</sup> to Predict the Percutaneous Absorption of Chemicals under Finite Dose Conditions

A Mathematical Approach Using Strat-M<sup>®</sup> to Predict the Percutaneous Absorption of Chemicals under Finite Dose Conditions

Estimation of the percutaneous absorption is essential for the safety assessment of cosmetic and dermopharmaceutical products. Currently, an artificial membrane, Strat-M<sup>®</sup>, has been focused on as the tool which could obtain the permeation parameters close to the skin-derived va...

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Bibliographic Details
Main Authors: Ryoki Kunita, Takafumi Nishijima, Hiroaki Todo, Kenji Sugibayashi, Hitoshi Sakaguchi
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Pharmaceutics
Subjects:
percutaneous absorption
artificial skin membrane
Fick’s first law of diffusion
finite dose condition
safety assessment
Online Access:https://www.mdpi.com/1999-4923/14/7/1370

Internet

https://www.mdpi.com/1999-4923/14/7/1370

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