Ergothioneine, a dietary antioxidant improves amyloid beta clearance in the neuroretina of a mouse model of Alzheimer’s disease

Ergothioneine, a dietary antioxidant improves amyloid beta clearance in the neuroretina of a mouse model of Alzheimer’s disease

IntroductionErgothioneine (Ergo) is a naturally occurring dietary antioxidant. Ergo uptake is dependent on the transporter, organic cation transporter novel-type 1 (OCTN1) distribution. OCTN1 is highly expressed in blood cells (myeloid lineage cells), brain and ocular tissues that are likely predisp...

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Bibliographic Details
Main Authors: Printha Wijesinghe, Clayton A. Whitmore, Matthew Campbell, Charles Li, Miranda Tsuyuki, Eleanor To, Justin Haynes, Wellington Pham, Joanne A. Matsubara
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Neuroscience
Subjects:
ergothioneine
Alzheimer’s disease
neuroretina
amyloid beta (Aβ)
microglia
astrocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1107436/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2023.1107436/full

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