Protective effects of phosphodiesterase inhibitors on lung function and remodeling in a murine model of chronic asthma

Protective effects of phosphodiesterase inhibitors on lung function and remodeling in a murine model of chronic asthma

The aim of the present study was to compare the efficacy of a novel phosphodiesterase 4 and 5 inhibitor, LASSBio596, with that of dexamethasone in a murine model of chronic asthma. Lung mechanics (airway resistance, viscoelastic pressure, and static elastance), histology, and airway and lung parench...

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Bibliographic Details
Main Authors: Campos H.S., Xisto D.G., Oliveira M.B.G., Teixeira I., Negri E.M., Mauad T., Carnielli D., Lima L.M., Barreiro E.J., Faffe D.S., Zin W.A., Lapa e Silva J.R., Rocco P.R.M.
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2006-01-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Asthma
Lung function
Steroid
Phosphodiesterase inhibitors
BALB/c mice
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000200016

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000200016

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