Crosstalk between aryl hydrocarbon receptor (AhR) and BCL-2 pathways suggests the use of AhR antagonist to maintain normal differentiation state of mammary epithelial cells during BCL-2 inhibition therapy

Crosstalk between aryl hydrocarbon receptor (AhR) and BCL-2 pathways suggests the use of AhR antagonist to maintain normal differentiation state of mammary epithelial cells during BCL-2 inhibition therapy

Introduction: Activating the aryl hydrocarbon receptor upon exposure to environmental pollutants promotes development of breast cancer stem cell (CSCs). BCL-2 family proteins protect cancer cells from the apoptotic effects of chemotherapeutic drugs. However, the crosstalk between AhR and the BCL-2 f...

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Bibliographic Details
Main Authors: Abdullah Al-Dhfyan, Ayodele Alaiya, Falah Al-Mohanna, Mohamed W Attwa, Abdullah F AlAsmari, Saleh A Bakheet, Hesham M. Korashy
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Journal of Advanced Research
Subjects:
AhR/CYP1A1
Breast cancer stem cells
In vivo mice
BCL-2
Proteomics
Venetoclax
Online Access:http://www.sciencedirect.com/science/article/pii/S209012322200234X

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http://www.sciencedirect.com/science/article/pii/S209012322200234X

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