A positive feedback loop between Periostin and TGFβ1 induces and maintains the stemness of hepatocellular carcinoma cells via AP-2α activation

A positive feedback loop between Periostin and TGFβ1 induces and maintains the stemness of hepatocellular carcinoma cells via AP-2α activation

Abstract Background Liver cancer stem cells (LCSCs) play key roles in the metastasis, recurrence, and chemotherapeutic resistance of hepatocellular carcinoma (HCC). Our previous research showed that the POSTN gene is closely related to the malignant progression and poor prognosis of HCC. This study...

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Bibliographic Details
Main Authors: Gang Chen, Yi Wang, Xin Zhao, Xiao-zai Xie, Jun-gang Zhao, Tuo Deng, Zi-yan Chen, Han-bin Chen, Yi-fan Tong, Zhen Yang, Xi-wei Ding, Peng-yi Guo, Hai-tao Yu, Li-jun Wu, Si-na Zhang, Qian-dong Zhu, Jun-jian Li, Yun-feng Shan, Fu-xiang Yu, Zheng-ping Yu, Jing-lin Xia
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Hepatocellular carcinoma
Cancer stem cells
POSTN
AP-2α
Positive feedback loop
Online Access:https://doi.org/10.1186/s13046-021-02011-8

Internet

https://doi.org/10.1186/s13046-021-02011-8

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