Estradiol Protects against Noise-Induced Hearing Loss and Modulates Auditory Physiology in Female Mice

Estradiol Protects against Noise-Induced Hearing Loss and Modulates Auditory Physiology in Female Mice

Recent studies have identified sex-differences in auditory physiology and in the susceptibility to noise-induced hearing loss (NIHL). We hypothesize that 17β-estradiol (E<sub>2</sub>), a known modulator of auditory physiology, may underpin sex-differences in the response to noise trauma....

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Bibliographic Details
Main Authors: Benjamin Shuster, Ryan Casserly, Erika Lipford, Rafal Olszewski, Béatrice Milon, Shaun Viechweg, Kanisa Davidson, Jennifer Enoch, Mark McMurray, Mark A. Rutherford, Kevin K. Ohlemiller, Michael Hoa, Didier A. Depireux, Jessica A. Mong, Ronna Hertzano
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
noise-induced hearing loss
mouse model
estrogen
sex-differences
cochlear synaptopathy
inner ear
Online Access:https://www.mdpi.com/1422-0067/22/22/12208

Internet

https://www.mdpi.com/1422-0067/22/22/12208

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