Pharmacokinetics/pharmacodynamics of chloroquine and artemisinin-based combination therapy with primaquine

Pharmacokinetics/pharmacodynamics of chloroquine and artemisinin-based combination therapy with primaquine

Abstract Background Activation of hypnozoites of vivax malaria causes multiple clinical relapses, which contribute to the Plasmodium vivax burden and continuing transmission. Artemisinin-based combination therapy (ACT) is effective against blood-stage P. vivax but requires co-administration with pri...

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Bibliographic Details
Main Authors: André Daher, Ghait Aljayyoussi, Dhelio Pereira, Marcus V. G. Lacerda, Márcia A. A. Alexandre, Cristiana T. Nascimento, Júlio Castro Alves, Laís Bastos da Fonseca, Diego Medeiros Dias da Silva, Douglas Pereira Pinto, Danielle Fonseca Rodrigues, Ana Carolina Rios Silvino, Taís Nóbrega de Sousa, Cristiana Ferreira Alves de Brito, Feiko O. ter Kuile, David G. Lalloo
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Malaria Journal
Subjects:
Malaria
Plasmodium vivax
Anti-malarial treatment
Chloroquine
Mefloquine
Lumefantrine
Online Access:http://link.springer.com/article/10.1186/s12936-019-2950-4

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http://link.springer.com/article/10.1186/s12936-019-2950-4

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