4-methoxycinnamyl p-coumarate reduces neuroinflammation by blocking NF-κB, MAPK, and Akt/GSK-3β pathways and enhancing Nrf2/HO-1 signaling cascade in microglial cells

4-methoxycinnamyl p-coumarate reduces neuroinflammation by blocking NF-κB, MAPK, and Akt/GSK-3β pathways and enhancing Nrf2/HO-1 signaling cascade in microglial cells

The active compound, 4-methoxycinnamyl p-coumarate (MCC), derived from the rhizome of Etlingera pavieana (Pierre ex Gagnep) R.M.Sm., has been shown to exert anti-inflammatory effects in several inflammatory models. However, its effects on microglial cells remain elusive. In the current study, we aim...

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Bibliographic Details
Main Authors: Mayuree Poonasri, Sakulrat Mankhong, Natthakarn Chiranthanut, Klaokwan Srisook
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
4-methoxycinnamyl p-coumarate
Anti-neuroinflammatory activity
Microglial cell
Nitric oxide
Prostaglandins E2
Heme oxygenase-1
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223016062

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http://www.sciencedirect.com/science/article/pii/S0753332223016062

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