Inhibition of Lithium Sensitive Orai1/ STIM1 Expression and Store Operated Ca2+ Entry in Chorea-Acanthocytosis Neurons by NF-κB Inhibitor Wogonin

Inhibition of Lithium Sensitive Orai1/ STIM1 Expression and Store Operated Ca2+ Entry in Chorea-Acanthocytosis Neurons by NF-κB Inhibitor Wogonin

Background/Aims: The neurodegenerative disease Chorea-Acanthocytosis (ChAc) is caused by loss-of-function-mutations of the chorein-encoding gene VPS13A. In ChAc neurons transcript levels and protein abundance of Ca2+ release activated channel moiety (CRAC) Orai1 as well as its regulator STIM1/2 are...

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Bibliographic Details
Main Authors: Basma Sukkar, Stefan Hauser, Lisann Pelzl, Zohreh Hosseinzadeh, Itishri Sahu, Tamer al-Maghout, Abdulla Al Mamun Bhuyan, Nefeli Zacharopoulou, Christos Stournaras, Ludger Schöls, Florian Lang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Chorein
Neurons
Lithium
NFκB
Orai1
SOCE
Online Access:https://www.karger.com/Article/FullText/495229

Internet

https://www.karger.com/Article/FullText/495229

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