Inhibition of HSP90 distinctively modulates the global phosphoproteome of Leishmania mexicana developmental stages

Inhibition of HSP90 distinctively modulates the global phosphoproteome of Leishmania mexicana developmental stages

ABSTRACT Heat shock protein 90 (HSP90) is an evolutionarily conserved chaperone protein that plays a central role in the folding and maturation of a large array of client proteins. In the unicellular parasite Leishmania, the etiological agent of the neglected tropical disease leishmaniasis, treatmen...

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Bibliographic Details
Main Authors: Exequiel O. Porta, Liqian Gao, Paul W. Denny, Patrick G. Steel, Karunakaran Kalesh
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:Microbiology Spectrum
Subjects:
phosphorylation
Leishmania
protein kinases
HSP90
TMT labeling
LC-MS/MS
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02960-23

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https://journals.asm.org/doi/10.1128/spectrum.02960-23

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