Occupancy of pramipexole (Sifrol) at cerebral dopamine D2/3 receptors in Parkinson's disease patients

Occupancy of pramipexole (Sifrol) at cerebral dopamine D2/3 receptors in Parkinson's disease patients

Whereas positron emission tomography (PET) with the antagonist ligand [18F]fallypride reveals the composite of dopamine D2 and D3 receptors in brain, treatment of Parkinson's disease (PD) patients with the D3-prefering agonist pramipexole should result in preferential occupancy in the nucleus a...

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Bibliographic Details
Main Authors: Angela Deutschländer, Christian la Fougère, Kai Boetzel, Nathalie L. Albert, Franz-Josef Gildehaus, Peter Bartenstein, Guoming Xiong, Paul Cumming
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:NeuroImage: Clinical
Subjects:
Parkinson's disease
Pet
Fallypride
Pramipexole
Agonist
Dopamine receptors
Occupancy
Online Access:http://www.sciencedirect.com/science/article/pii/S221315821630105X

Internet

http://www.sciencedirect.com/science/article/pii/S221315821630105X

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