Proteomic Analysis of Synovial Fibroblasts and Articular Chondrocytes Co-Cultures Reveals Valuable VIP-Modulated Inflammatory and Degradative Proteins in Osteoarthritis

Proteomic Analysis of Synovial Fibroblasts and Articular Chondrocytes Co-Cultures Reveals Valuable VIP-Modulated Inflammatory and Degradative Proteins in Osteoarthritis

Osteoarthritis (OA) is the most common musculoskeletal disorder causing a great disability and a reduction in the quality of life. In OA, articular chondrocytes (AC) and synovial fibroblasts (SF) release innate-derived immune mediators that initiate and perpetuate inflammation, inducing cartilage ex...

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Bibliographic Details
Main Authors: Selene Pérez-García, Valentina Calamia, Tamara Hermida-Gómez, Irene Gutiérrez-Cañas, Mar Carrión, Raúl Villanueva-Romero, David Castro, Carmen Martínez, Yasmina Juarranz, Francisco J. Blanco, Rosa P. Gomariz
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
osteoarthritis
synovial fibroblasts
chondrocytes
VIP
CHI3L1
PTX3
Online Access:https://www.mdpi.com/1422-0067/22/12/6441

Internet

https://www.mdpi.com/1422-0067/22/12/6441

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