A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells

A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells

Abstract Background Human T-cell leukemia virus type 1 (HTLV-1) infects primarily CD4+ T-lymphocytes and evoques severe diseases, predominantly Adult T-Cell Leukemia/ Lymphoma (ATL/L) and HTLV-1-associated Myelopathy/ Tropical Spastic Paraparesis (HAM/TSP). The viral transactivator of the pX region...

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Bibliographic Details
Main Authors: Sebastian Millen, Lina Meretuk, Tim Göttlicher, Sarah Schmitt, Bernhard Fleckenstein, Andrea K. Thoma-Kress
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Retrovirology
Subjects:
HTLV-1
Tax-1
NF-κB
M22
Protein stability
IKK2
Online Access:http://link.springer.com/article/10.1186/s12977-020-00538-w

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http://link.springer.com/article/10.1186/s12977-020-00538-w

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