Transcriptome analyses of the cortex and white matter of focal cortical dysplasia type II: Insights into pathophysiology and tissue characterization

Transcriptome analyses of the cortex and white matter of focal cortical dysplasia type II: Insights into pathophysiology and tissue characterization

IntroductionFocal cortical dysplasia (FCD) is a common cause of pharmacoresistant epilepsy. According to the 2022 International League Against Epilepsy classification, FCD type II is characterized by dysmorphic neurons (IIa and IIb) and may be associated with balloon cells (IIb). We present a multic...

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Main Authors: Guilherme Rossi Assis-Mendonça, Maria Carolina Pedro Athié, João Vitor Gerdulli Tamanini, Arethusa de Souza, Gabriel Gerardini Zanetti, Patrícia Aline Oliveira Ribeiro de Aguiar Araújo, Enrico Ghizoni, Helder Tedeschi, Marina Koutsodontis Machado Alvim, Vanessa Simão de Almeida, Welliton de Souza, Roland Coras, Clarissa Lin Yasuda, Ingmar Blümcke, André Schwambach Vieira, Fernando Cendes, Iscia Lopes-Cendes, Fabio Rogerio
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Neurology
Subjects:
focal cortical dysplasia
transcriptome
cholesterol biosynthesis enzymes
humanin-like 12
GPNMB
molecular biomarker
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2023.1023950/full

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https://www.frontiersin.org/articles/10.3389/fneur.2023.1023950/full

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