Targeting ROR2 homooligomerization disrupts ROR2-dependent signaling and suppresses stem-like cell properties of human breast adenocarcinoma

Targeting ROR2 homooligomerization disrupts ROR2-dependent signaling and suppresses stem-like cell properties of human breast adenocarcinoma

Summary: Breast cancer stem-like cells (CSCs) are enriched following treatment with chemotherapy, and posited as having a high level of plasticity and enhanced tumor-initiation capacity, which can enable cancer relapse. Here, we show that such features are shared by breast cancer (BCA) cells that ex...

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Bibliographic Details
Main Authors: Feng Leng, Jiajia Huang, Liufeng Wu, Jianchao Zhang, Xinxin Lin, Ruhuan Deng, Jinhang Zhu, Zhen Li, Zhenghao Li, Yimeng Wang, Han Zhang, Desheng Lu, Thomas J. Kipps, Suping Zhang
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:iScience
Subjects:
Stem cell plasticity
Molecular interaction
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224028165

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http://www.sciencedirect.com/science/article/pii/S2589004224028165

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