Systemic prime mucosal boost significantly increases protective efficacy of bivalent RSV influenza viral vectored vaccine

Abstract Although licensed vaccines against influenza virus have been successful in reducing pathogen-mediated disease, they have been less effective at preventing viral infection of the airways and current seasonal updates to influenza vaccines do not always successfully accommodate viral drift. Mo...

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Bibliographic Details
Main Authors: Cameron Bissett, Sandra Belij-Rammerstorfer, Marta Ulaszewska, Holly Smith, Reshma Kailath, Susan Morris, Claire Powers, Sarah Sebastian, Hannah R. Sharpe, Elizabeth R. Allen, Ziyin Wang, Robert F. Cunliffe, Hadijatou J. Sallah, Alexandra J. Spencer, Sarah Gilbert, John S. Tregoning, Teresa Lambe
Format: Article
Language:English
Published: Nature Portfolio 2024-06-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-024-00912-1