Accumulation of free cholesterol and oxidized low-density lipoprotein is associated with portal inflammation and fibrosis in nonalcoholic fatty liver disease

Accumulation of free cholesterol and oxidized low-density lipoprotein is associated with portal inflammation and fibrosis in nonalcoholic fatty liver disease

Abstract Background Macrophages engulf oxidized-LDL (oxLDL) leading to accumulation of cellular cholesterol and formation of foam cells, which is a hallmark of atherosclerosis. Moreover, recent studies showed that accumulation of free cholesterol in macrophages leading to activation of NLRP3 inflamm...

Full description

Bibliographic Details
Main Authors: Cheng-Maw Ho, Shu-Li Ho, Yung-Ming Jeng, Yu-Sheng Lai, Ya-Hui Chen, Shao-Chun Lu, Hui-Ling Chen, Po-Yuan Chang, Rey-Heng Hu, Po-Huang Lee
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Journal of Inflammation
Subjects:
Nonalcoholic fatty liver disease
Steatohepatitis
Oxidized low-density lipoprotein
Online Access:http://link.springer.com/article/10.1186/s12950-019-0211-5

Internet

http://link.springer.com/article/10.1186/s12950-019-0211-5

Similar Items