Dendrobium officinale Polysaccharide Protected CCl4-Induced Liver Fibrosis Through Intestinal Homeostasis and the LPS-TLR4-NF-κB Signaling Pathway

Dendrobium officinale Polysaccharide Protected CCl4-Induced Liver Fibrosis Through Intestinal Homeostasis and the LPS-TLR4-NF-κB Signaling Pathway

We explored the therapeutic effects of Dendrobium officinale polysaccharide (DOP) on CCl4-induced liver fibrosis with respect to the intestinal hepatic axis using a rat model. Histopathological staining results showed that DOP alleviated extensive fibrous tissue proliferation in interstitium and les...

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Bibliographic Details
Main Authors: Kaiping Wang, Xiawen Yang, Zhijing Wu, Hongjing Wang, Qiang Li, Hao Mei, Ruxu You, Yu Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
Dendrobium officinale polysaccharide
liver fibrosis
intestinal tight junction
apoptosis
TLR4/NF-κB pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00240/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00240/full

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