The Effects of Dietary Advanced Glycation End-Products on Neurocognitive and Mental Disorders
Advanced glycation end products (AGEs) are glycated proteins or lipids formed endogenously in the human body or consumed through diet. Ultra-processed foods and some culinary techniques, such as dry cooking methods, represent the main sources and drivers of dietary AGEs. Tissue accumulation of AGEs...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/12/2421 |
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| author | Nathan M. D’Cunha Domenico Sergi Melissa M. Lane Nenad Naumovski Elizabeth Gamage Anushri Rajendran Matina Kouvari Sarah Gauci Thusharika Dissanayka Wolfgang Marx Nikolaj Travica |
| author_facet | Nathan M. D’Cunha Domenico Sergi Melissa M. Lane Nenad Naumovski Elizabeth Gamage Anushri Rajendran Matina Kouvari Sarah Gauci Thusharika Dissanayka Wolfgang Marx Nikolaj Travica |
| author_sort | Nathan M. D’Cunha |
| collection | DOAJ |
| description | Advanced glycation end products (AGEs) are glycated proteins or lipids formed endogenously in the human body or consumed through diet. Ultra-processed foods and some culinary techniques, such as dry cooking methods, represent the main sources and drivers of dietary AGEs. Tissue accumulation of AGEs has been associated with cellular aging and implicated in various age-related diseases, including type-2 diabetes and cardiovascular disease. The current review summarizes the literature examining the associations between AGEs and neurocognitive and mental health disorders. Studies indicate that elevated circulating AGEs are cross-sectionally associated with poorer cognitive function and longitudinally increase the risk of developing dementia. Additionally, preliminary studies show that higher skin AGE accumulation may be associated with mental disorders, particularly depression and schizophrenia. Potential mechanisms underpinning the effects of AGEs include elevated oxidative stress and neuroinflammation, which are both key pathogenetic mechanisms underlying neurodegeneration and mental disorders. Decreasing dietary intake of AGEs may improve neurological and mental disorder outcomes. However, more sophisticated prospective studies and analytical approaches are required to verify directionality and the extent to which AGEs represent a mediator linking unhealthy dietary patterns with cognitive and mental disorders. |
| first_indexed | 2024-03-09T22:49:57Z |
| format | Article |
| id | doaj.art-079dc9d1cbdf467a99a03754c99d3c15 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T22:49:57Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-079dc9d1cbdf467a99a03754c99d3c152023-11-23T18:20:47ZengMDPI AGNutrients2072-66432022-06-011412242110.3390/nu14122421The Effects of Dietary Advanced Glycation End-Products on Neurocognitive and Mental DisordersNathan M. D’Cunha0Domenico Sergi1Melissa M. Lane2Nenad Naumovski3Elizabeth Gamage4Anushri Rajendran5Matina Kouvari6Sarah Gauci7Thusharika Dissanayka8Wolfgang Marx9Nikolaj Travica10Discipline of Nutrition and Dietetics, Faculty of Health, University of Canberra, Canberra, ACT 2601, AustraliaDepartment of Translational Medicine, University of Ferrara, 44121 Ferrara, ItalyFood and Mood Centre, IMPACT—The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, VIC 3220, AustraliaDiscipline of Nutrition and Dietetics, Faculty of Health, University of Canberra, Canberra, ACT 2601, AustraliaFood and Mood Centre, IMPACT—The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, VIC 3220, AustraliaFood and Mood Centre, IMPACT—The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, VIC 3220, AustraliaDiscipline of Nutrition and Dietetics, Faculty of Health, University of Canberra, Canberra, ACT 2601, AustraliaCentre for Human Psychopharmacology, Swinburne University, Melbourne, VIC 3122, AustraliaFood and Mood Centre, IMPACT—The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, VIC 3220, AustraliaFood and Mood Centre, IMPACT—The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, VIC 3220, AustraliaFood and Mood Centre, IMPACT—The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, VIC 3220, AustraliaAdvanced glycation end products (AGEs) are glycated proteins or lipids formed endogenously in the human body or consumed through diet. Ultra-processed foods and some culinary techniques, such as dry cooking methods, represent the main sources and drivers of dietary AGEs. Tissue accumulation of AGEs has been associated with cellular aging and implicated in various age-related diseases, including type-2 diabetes and cardiovascular disease. The current review summarizes the literature examining the associations between AGEs and neurocognitive and mental health disorders. Studies indicate that elevated circulating AGEs are cross-sectionally associated with poorer cognitive function and longitudinally increase the risk of developing dementia. Additionally, preliminary studies show that higher skin AGE accumulation may be associated with mental disorders, particularly depression and schizophrenia. Potential mechanisms underpinning the effects of AGEs include elevated oxidative stress and neuroinflammation, which are both key pathogenetic mechanisms underlying neurodegeneration and mental disorders. Decreasing dietary intake of AGEs may improve neurological and mental disorder outcomes. However, more sophisticated prospective studies and analytical approaches are required to verify directionality and the extent to which AGEs represent a mediator linking unhealthy dietary patterns with cognitive and mental disorders.https://www.mdpi.com/2072-6643/14/12/2421AGEneurodegenerative diseasescognitive functiondementiadepressionmental health |
| spellingShingle | Nathan M. D’Cunha Domenico Sergi Melissa M. Lane Nenad Naumovski Elizabeth Gamage Anushri Rajendran Matina Kouvari Sarah Gauci Thusharika Dissanayka Wolfgang Marx Nikolaj Travica The Effects of Dietary Advanced Glycation End-Products on Neurocognitive and Mental Disorders Nutrients AGE neurodegenerative diseases cognitive function dementia depression mental health |
| title | The Effects of Dietary Advanced Glycation End-Products on Neurocognitive and Mental Disorders |
| title_full | The Effects of Dietary Advanced Glycation End-Products on Neurocognitive and Mental Disorders |
| title_fullStr | The Effects of Dietary Advanced Glycation End-Products on Neurocognitive and Mental Disorders |
| title_full_unstemmed | The Effects of Dietary Advanced Glycation End-Products on Neurocognitive and Mental Disorders |
| title_short | The Effects of Dietary Advanced Glycation End-Products on Neurocognitive and Mental Disorders |
| title_sort | effects of dietary advanced glycation end products on neurocognitive and mental disorders |
| topic | AGE neurodegenerative diseases cognitive function dementia depression mental health |
| url | https://www.mdpi.com/2072-6643/14/12/2421 |
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