Direct Reprogramming and Induction of Human Dermal Fibroblasts to Differentiate into iPS-Derived Nucleus Pulposus-like Cells in 3D Culture

Direct Reprogramming and Induction of Human Dermal Fibroblasts to Differentiate into iPS-Derived Nucleus Pulposus-like Cells in 3D Culture

Intervertebral disc (IVD) diseases are common spinal disorders that cause neck or back pain in the presence or absence of an underlying neurological disorder. IVD diseases develop on the basis of degeneration, and there are no established treatments for degeneration. IVD diseases may therefore repre...

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Bibliographic Details
Main Authors: Shoji Seki, Mami Iwasaki, Hiroto Makino, Yasuhito Yahara, Yoshitaka Miyazaki, Katsuhiko Kamei, Hayato Futakawa, Makiko Nogami, Nguyen Tran Canh Tung, Tatsuro Hirokawa, Mamiko Tsuji, Yoshiharu Kawaguchi
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
intervertebral disc disease
human dermal fibroblast
nucleus pulposus cell
alginate beads
direct reprogramming
intervertebral disc regeneration
Online Access:https://www.mdpi.com/1422-0067/23/7/4059

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https://www.mdpi.com/1422-0067/23/7/4059

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