Cyclin D1 Stability Is Partly Controlled by O-GlcNAcylation

Cyclin D1 Stability Is Partly Controlled by O-GlcNAcylation

Cyclin D1 is the regulatory partner of the cyclin-dependent kinases (CDKs) CDK4 or CDK6. Once associated and activated, the cyclin D1/CDK complexes drive the cell cycle entry and G1 phase progression in response to extracellular signals. To ensure their timely and accurate activation during cell cyc...

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Bibliographic Details
Main Authors: Louis Masclef, Vanessa Dehennaut, Marlène Mortuaire, Céline Schulz, Maïté Leturcq, Tony Lefebvre, Anne-Sophie Vercoutter-Edouart
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Endocrinology
Subjects:
cyclin D
O-GlcNAc
stability
ubiquitination
cell cycle
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00106/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2019.00106/full

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