Evolution of the vls Antigenic Variability Locus of the Lyme Disease Pathogen and Development of Recombinant Monoclonal Antibodies Targeting Conserved VlsE Epitopes

Evolution of the vls Antigenic Variability Locus of the Lyme Disease Pathogen and Development of Recombinant Monoclonal Antibodies Targeting Conserved VlsE Epitopes

ABSTRACT VlsE (variable major protein-like sequence, expressed) is an outer surface protein of the Lyme disease pathogen (Borreliella species) responsible for its within-host antigenic variation and a key diagnostic biomarker of Lyme disease. However, the high sequence variability of VlsE poses a ch...

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Bibliographic Details
Main Authors: Li Li, Lia Di, Saymon Akther, Brian M. Zeglis, Weigang Qiu
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:Microbiology Spectrum
Subjects:
Borrelia burgdorferi
C6 peptide
Lyme disease
VlsE
monoclonal antibodies
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01743-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.01743-22

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