Analyzing the ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets

Analyzing the ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets

Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron (MN) disease with severely limited treatment options. Identification of effective treatments has been limited in part by the lack of predictive animal models for complex human disorders. Here, we utilized pharmacologic ER stressors t...

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Bibliographic Details
Main Authors: Michelle E. Watts, Richard M. Giadone, Alban Ordureau, Kristina M. Holton, J. Wade Harper, Lee L. Rubin
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
ALS
ER stress
iPSCs
motor neurons
proteomics
phosphoproteomics
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1327361/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2023.1327361/full

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