PPAR-α Insufficiency Enhances Doxorubicin-Induced Nephropathy in PPAR-α Knockout Mice and a Murine Podocyte Cell Line

PPAR-α Insufficiency Enhances Doxorubicin-Induced Nephropathy in PPAR-α Knockout Mice and a Murine Podocyte Cell Line

Peroxisome proliferator-activated receptor-alpha (PPAR-α) and its exogenous activators (fibrates) promote autophagy. However, whether the deleterious effects of PPAR-α deficiency on doxorubicin (DOX)-induced podocytopathy are associated with reduced autophagy remains to be clarified. We investigated...

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Bibliographic Details
Main Authors: Kohei Matsuta, Kazuko Kamiyama, Toru Imamoto, Izumi Takeda, Shinya Masunaga, Mamiko Kobayashi, Naoki Takahashi, Kenji Kasuno, Masanori Hara, Masayuki Iwano, Tadashi Toyama, Hideki Kimura
Format: Article
Language:English
Published: MDPI AG 2024-08-01
Series:Cells
Subjects:
PPAR-α
podocyte
glomerulosclerosis
autophagy
p62
AMPK
Online Access:https://www.mdpi.com/2073-4409/13/17/1446

Internet

https://www.mdpi.com/2073-4409/13/17/1446

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